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The critical storage protocols, specifically refrigeration and the 28-day rule, only begin *after* you have opened the vial for the first time
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10.1016/j.ejphar.2019.172593 137 TabataY.NaganoA.IkadaY
A 2020 preclinical safety evaluation (Xu et al., 2020, Regul Toxicol Pharmacol ) confirmed a favorable profile at research-relevant doses with no significant organ toxicity at tested concentrations
The highest fold change in the gene level - approximately 44 times higher in IL-8 expression, was observed in 580 M CuCl 2 treated cells when compared to control
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