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In susceptible individuals, progesteronewhether produced by the body or introduced syntheticallycan trigger mast cell degranulation , a process in which immune cells release inflammatory mediators, most notably histamine

Regular exercise improves insulin sensitivity and can enhance the medication's effects on weight management, though intense exercise may temporarily increase appetite in some individuals

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There is also growing interest in whether GLP-1 medications may help with nicotine dependence, binge eating disorder, and other compulsive reward-driven behaviors, says Anton