Krahenbuhl S, Reichen J
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Demmel V et al
Ozempic works through several mechanisms: it stimulates insulin secretion when blood glucose levels are elevated, suppresses the release of glucagon (a hormone that raises blood sugar), slows gastric emptying to reduce post-meal glucose spikes, and acts on appetite centres in the brain to promote satiety
Many patients in the trial were also receiving standard-of-care therapies for their underlying cardiovascular disease, with 90.1% of patients taking lipid-lowering medications, 86.2% antiplatelets, 70.2% beta-blockers, 45.0% ACE inhibitors and 29.5% ARBs