sitagliptin Sitagliptin Trade Name: Januvia Drug Class: oral hypoglycemics Mechanism of Action: An inhibitor of dipeptidyl peptidase-4 (DPP-4), a protease that degrades the incretin GLP-1 Incretins are hormones released from the GI tract in response to nutrient ingestion Incretins potentiate glucose-stimulated insulin secretion from beta cells in the pancreas As a result of inhibiting DPP-4, increased or prolonged GLP-1 levels are able to potentiate the secretion of insulin by the pancreas The effect produced by DPP-4 inhibitors is dependent on endogenous GLP-1 levels, and produce a modest effect on GLP-1 activity compared to giving GLP-1 receptor agonists (hence DPP-4 inhibitors do not have the same impact to produce weight loss as GLP-1 agonists)
It has been shown to heal ulcers, reduce inflammation, and protect the lining of the stomach and intestines
Cost, Access, and Treatment Personalization at PlexusDx Metformin remains the most affordable diabetes medication, available as a generic for just a few dollars per month
Nephrol Dial Transplant 38(9):20412051 Ruze R, Liu T, Zou X, Song J, Chen Y, Xu R et al (2023) Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments
Some of the possible side effects of consuming too much protein include weight gain, kidney issues, constipation and bad breath