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These effects are processed by a specific sequence of neurotransmitters beginning within domains of the ARC that consist of orexigenic neurons expressing neuropeptide Y (NPY) and Agouti-related peptide (AgRP) as well as domains that consist of anorexigenic neurons expressing pro-opiomelanocortin, POMC (yielding the neurotransmitter -MSH) and cocaine and amphetamine-regulated transcript (CART)

Many patients begin to see weight loss results within the first few weeks of treatment , with more significant results typically occurring over several months

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McBride JM, Radzwich R, Mangino L, McCormick M, McCormick T, Volek JS, Bush JA, Augilera B, Newton RU, Kraemer WJ