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Figure 3 Pectin methylesterase (PME) activity of C
Some patients hold at 5mg or 7.5mg for eight or even twelve weeks before escalating, achieving excellent results without the side effect intensity of rapid titration
But what exactly does that mean
Outcomes depend on multiple factors, including starting health status, adherence to treatment, nutrition, and physical activity
If proper titration starting at the lowest dose with gradual 4-week escalation still produces intolerable GI effects, split dosing may allow continued use of the medication rather than abandoning it entirely
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