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It may protect collagen and elastin fibres, which are essential for maintaining skin structure, firmness, and elasticity

Ozempic is a once-weekly injectable medication that lowers blood glucose levels by increasing insulin secretion from the pancreas when blood sugar levels are high

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Avoid the inner thigh, where skin is thinner and blood vessels are closer to the surface

These represent areas requiring careful clinical assessment rather than definitive UK contraindications, as formal eligibility criteria for retatrutide cannot yet be established in the absence of regulatory approval