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It alters the colour of the iris and may distort the shape of the pupil
Food and Drug Administration (FDA) approves the use of semaglutide for weight loss if you meet one of two criteria
Less Common but Serious Side Effects Some less common but more serious GLP-1 side effects are worth being aware of: Pancreatitis (inflammation of the pancreas) Gallbladder problems (including gallstones) Acute kidney injury (usually as a result of severe dehydration from vomiting or diarrhea) Diabetic retinopathy worsening (particularly in patients with rapid improvement in blood sugar control) Hypoglycemia (when combined with other diabetes medications like sulfonylureas or insulin) All GLP-1 medications also carry a warning regarding a theoretical risk of medullary thyroid carcinoma, based on animal studies
It is difficult to compare the efficacy of GUB014295 with competitors at this early stage, but more advanced drug candidates are achieving weight loss in excess of 20% from baseline in Phase II and III clinical trials, Blackstock told us
FDA approval of metformin for diabetes does not mean FDA approval for longevity use - those are distinct regulatory determinations, and the longevity indication is off-label
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