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While compelling, a lack of clinical evidence has left researchers skeptical of Akkermansias efficacy, warning that more studies are needed
Guo L, Moss SE, Alexander RA, Ali RR, Fitzke FW, Cordeiro MF
Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial
Its core physiological function is to catalyze the methylation of nicotinamide (NAM, a key precursor for NAD+ synthesis) with Sadenosylmethionine (SAM) to produce 1methylnicotinamide (1MNA)
& Dosio, F
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