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Cystine declined from 0.42 mg g -1 in the control to 0.33 mg g -1 at 300 g L -1 Pb, followed by an increase to 0.48 mg g -1 at 500 g L -1 Pb (Figure 8)

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Therefore, decreased NCOA4 expression and impaired binding of NCOA4 to FTH1 diminish the FTH1 degradation by downregulating ferritinophagy, and decreased FPN1 expression inhibits iron output and release to other tissues, both of which effectively increase liver iron overload and, in turn, trigger oxidative stress and ferroptosis (82)

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In a meta-analysis of studies on non-small cell lung cancer patients, astragalus-based traditional Chinese herbal formulas increased the effectiveness of platinum-based chemotherapy, reducing one-year mortality by 33% and improving tumor response, and reduced side effects (McCulloch 2006)