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The mean baseline body weight was 108 kg, and mean BMI was 37 kg/m2

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NF-B Pathway LPO products such as 4-HNE have been shown to interfere with NF-B activation at the level of IB kinase (IKK) which is an important molecule phosphory-lating IB for its degradation [14, 128]

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Clinical characteristics from EHR data such as relevant comorbid conditions, medication history and prior procedures were included if captured within the two years prior to the index date

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