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The targeted 3-PLG-ibu-A-GSH and ibuprofen at higher, 1.5 M concentration (the estimated drug content of the 3-PLG-ibu-A-GSH nanocarriers) significantly protected against the barrier damaging effect of cytokines with the ibuprofen-coupled targeted nanocarrier group showing the highest effect against BBB dysfunction (Fig
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doi: 10.3389/fcell.2022.806081 Received 31 October 2021 Accepted 03 February 2022 Published 03 March 2022 Volume 10 - 2022 Edited by Xiongwen Chen, Temple University, United States Reviewed by Qian Xiang, Peking University First Hospital, China Jamal Bouitbir, University of Basel, Switzerland Updates Copyright 2022 Zhang, Qu, Chen, Luo, Chen, Xiao, Ding, Zhao, Lu, Chen and Yu