Glutathione is a tripeptide made from three amino acids (glutamate, cysteine, and glycine), and cysteine is the bottleneck: your body typically has plenty of glutamate and glycine, but cysteine availability limits how much glutathione you can produce
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Tayran H, Yilmaz E, Bhattarai P et al (2024b) ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimers disease through BDNF/NGFR signaling
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Notably, rodents have only the first four GPx isoenzymes (GPx1-GPx4) as the selenoenzymes and the remaining four (GPx4-GPx8) as the cysteine-containing enzymes [1, 8, 9]