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In the setting of gut-derived neuroinflammation, ISR activation robustly promoted transcription of LD biogenesis genes, leading to excessive neutral-lipid accumulation in microglia, whereas pharmacological ISR blockade (with ISRIB) largely reversed the LD burden evoked by inflammatory stimuli, confirming the causal role of ISR in lipotoxic injury

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Liraglutide has demonstrated both cardiovascular benefits in addition to its excellent glucose-lowering effects

Best JH, Boye KS, Rubin RR, Cao D, Kim TH, Peyrot M

Its worth noting that in a 2015 study, a single dose of glutamine administered to participants was associated with an increased meal size