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Ongoing Clinical Trials Multiple Phase 3 trials are currently enrolling or analyzing data: REDEFINE program Examining cagrilintide monotherapy across diverse populations, including studies focused on long-term safety and efficacy beyond the initial 32-week trials

Mechanistically the peptide is hypothesised to act as a 'gene-regulatory short peptide': because of its small size it is proposed to reach the nucleus intact and to bind DNA at specific motifs

PMID 20143256 Pfizer/Hospira