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Tyrosinase is the enzyme that converts signals UV exposure, inflammation, hormonal triggers into melanin production
Here, we present new evidence in -cells and primary mouse and human islets demonstrating that, following agonist binding and internalisation, endosomal GLP-1R binds to endoplasmic reticulum (ER)-localised ER-mitochondria membrane contact site (ERMCS) organising factor VAPB to locally engage SPHKAP, an A-kinase anchoring protein (AKAP) whose gene coding variants have been linked to T2D and high BMI risk in genome-wide association studies (GWAS)
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