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Cryan JF, ORiordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, et al

Only a small, tightly packed amount of material should be used

Against this background, reports that GLP-1 secretion from L-cells is reduced in patients with type 2 diabetes [10, 11] have prompted several hypotheses about how this affects the estimated clinical effectiveness of these novel drugs

More serious but rare concerns include pancreatitis, gallbladder problems, and potential thyroid tumor risk (observed in rodent studies but not confirmed in humans)

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