Furthermore, PPAR- can reduce the expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), low density lipoprotein receptor (LDLR), and cytochrome P450 family 7 subfamily A polypeptide 1 (CYP7A1) via both dependent and independent pathways, disrupting the balance of cholesterol metabolism [78]
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