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There are some data to suggest that insulin resistance also occurs in PD [70], however, this is controversial since systemic insulin resistance is not present in de novo, medication-free PD patients [71], and brain insulin resistance is not present in cognitively normal PD cases [72]

PMID: 34900526

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Additionally, semaglutide has been shown to have a comparable risk profile to other GLP-1 RAs with respect to gastrointestinal adverse effects in the IBD population (106)

Once opened, semaglutide can stay at room temperature up to 28 days if kept away from heat and light