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Notably, Kla modification plays a key role in the tumor immune microenvironment (TIME), reshaping immune cell functions, such as inhibiting the activity of T cells and NKT cells and enhancing the immunosuppressive function of Tregs

IF may also enhance metabolic health and strengthen resilience against chronic inflammatory conditions, such as diabetes and cardiovascular diseases, by reducing the accumulation of cellular debris [30]

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On the other hand, excessive intake of certain nutrients, such as iron and copper, can increase oxidative stress and disrupt metal homeostasis, leading to tissue damage and impaired detoxification

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