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Together, this work provides a conceptual and experimental framework for developing adjunct therapies aimed at maintaining weight loss by targeting glucocorticoid signaling pathways, addressing a major unmet need in obesity treatment and offering new avenues for improving the long-term efficacy of current pharmacotherapies
The impact of changed redoxin function on ferroptosis could also be based on secondary effects, e.g., the increase in superoxide formation upon loss of mitochondrial redoxins [90,91] or activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway [92,93] , a major regulator of transcription of antioxidant and anti-ferroptotic enzymes [65]
The capacity of these drugs to increase insulin secretion and suppress glucagon release leads not only to better blood sugar control but also to a better cardiovascular profile, putting them in a favorable position in the treatment of type 2 diabetes
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