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Circadian pathway Modulation of the circadian rhythm Regulates sleep-wake cycles Normalizes sleep disorders Effects lasting several days Opioid route Endogenous opioid system Pain perception module Blocked by naloxone Supports weaning management Stress response Hypothalamic-pituitary-adrenal axis Reduces stress responses Reduces cortisol secretion Improves stress management Unique biological properties Unlike most peptides, DSIP freely crosses the blood-brain barrier and can be absorbed by the intestine without enzymatic degradation

This was observed through better tissue oxygenation and heart rate after supplementing with CoQ10 ( Summary: CoQ10 can reduce oxidative damage and inflammation that results in diseases of the lungs

DSIPs ability to enhance sleep quality during whatever window is available makes it potentially valuable for this population

The research strategy for these compounds is fundamentally different because their pharmacokinetics are different