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Since baseline collagen production is known to decline roughly 1% per year starting in the mid-20s, a compound that reactivates a suppressed signaling pathway rather than simply adding raw material is mechanistically interesting in a way that most topical actives aren't

IGF-1 LR3 bypasses the entire hypothalamic-pituitary-somatotropic axis, delivering IGF-1 receptor activation regardless of upstream hormonal status

Teichret J, Hermann R, Ruus P, Preiss R (2003) Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers

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