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10.1080/15548627.2023.2213984 Autophagy 50 LiR.LiR.XieJ.ChenJ.LiuS.PanA.et al (2023)
Who can be a good candidate for GLP-1
A recent study showed that glucose metabolism was dysregulated and that pyruvate supplementation could prevent neurodegeneration in an animal model of glaucoma 31 , suggesting that ATP production from glycolysis is disrupted, and that other energy fuel pathways, such as -oxidation, may be augmented to compensate for the reduction in energy metabolism
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When inflammation-related cellular dysfunction is considered, the revised RT-qPCR data further highlight alterations in neurotrophic signalling pathways, in line with experimental work showing that GLP1 receptor activation enhances cAMP/PKAdependent CREB signalling and BDNF expression in the diabetic and degenerating brain [30,39]
