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Compound C was preincubated with FLS for 12 h to inhibit the activation of AMPK in advance, and FLS were then treated with l-carnitine for another 24 h

Lancet (1999) 353(9167):18659

This highlights the critical need for novel, well-tolerated, and with alternative mechanisms to broaden MDD treatment options, especially Acetyl-L-Carnitine (ALC)

The next step was to investigate if these improvements in half-lives could be transposed in vivo