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While pineal melatonin regulates the circadian rhythms, extra pineal melatonin performs various functions beyond its primary role, which includes acting as an antioxidant, stimulating the production of endogenous antioxidant enzymes, scavenging free radicals, and playing a homeostatic role within mitochondria (ArandaMartnez et al

1 The mMRC ranges from grade 0 (breathless with strenuous exercise only) to grade 4 (too breathless to leave house or while dressing or undressing)

Treatment cycle and timeline of effects Treatment may follow a cycle

Vitamin B12 IV Infusion Protocols For IV B12, the vitamin is mixed with saline and given slowly

The 4-month rest is not optional