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It enables investigation of appetite regulation, glucose homeostasis, and energy balance through integrated endocrine signaling across coordinated metabolic receptor pathways

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Activation of oncogenes such as RAS and MYC, along with metabolic reprogramming phenomena like the Warburg effect, further amplify intracellular ROS generation, establishing a reinforcing cycle that perpetuates tumor development [34]

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2012;10(12):e1001450