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Tirzepatide has shown superior glycemic control compared to other GLP-1s, likely due to its dual action on GIP and GLP-1 receptors
It is a triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors)
Profile 3: Poorly Controlled or Unstable Psychiatric Illness Semaglutide and tirzepatide carry no specific psychiatric black box warning, but the FDA's Adverse Event Reporting System (FAERS) contains post-marketing reports of suicidal ideation associated with GLP-1 agents, prompting the FDA to open a signal evaluation in 2023 [7]
In these cases, symptoms can persist for several months, especially if the dosage is increased too quickly or if there are other factors at play, such as dietary habits or pre-existing gastrointestinal conditions
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