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While lipid-based nanoparticles (LNPs) have garnered significant clinical traction, evidenced by their successful deployment in mRNA vaccines and offering promise for challenging therapeutics like PROTACs (Table 2) [209, 210], the path to clinical translation for nanocarrier-based PROTAC delivery is fraught with hurdles

discussion 27-18

Overall, PCOS is characterized by oligomenorrhea, anovulation, clinical and/or biochemical hyperandrogenism, and polycystic ovarian morphology, variably combined to generate different diagnostic criteria, among which the most used are the Rotterdam criteria [3]

It was specifically developed to stimulate endogenous growth hormone release through selective activation of the growth hormone secretagogue receptor (GHS-R1a), also known as the ghrelin receptor

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