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There is currently no evidence suggesting that post-cholecystectomy patients experience increased tirzepatide-related adverse effects compared to those with intact gallbladders

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (marketed as Mounjaro) and chronic weight management (marketed as Zepbound)

*Correspondence: Vi Lien Yap, [email protected]

10.1210/jc.2006-1806 25 GoldsteinA

6 Alternatively, some patients may be prescribed sulfonylureas or thiazolidiniones to improve insulin secretion, but both of these treatment options are associated with an elevated risk of heart failure making them unsuitable for use in patients with cardiovascular disease