use alternative contraceptive methods during treatment initiation and for 4 weeks after each dose escalation [11] Concomitant medications: Avoid coadministration with other GLP-1 receptor agonists for weight management Patients should be advised to seek medical attention for: Severe, persistent abdominal pain that may radiate to the back (potential pancreatitis) Signs of thyroid tumors including neck mass, dysphagia, dyspnea, or persistent hoarseness Symptoms of acute gallbladder disease (right upper quadrant pain, fever, jaundice) Severe gastrointestinal symptoms leading to dehydration Changes in vision or signs of hypoglycemia Signs of hypersensitivity reactions including rash, itching, or difficulty breathing Clinicians should conduct a thorough medical history before initiating tirzepatide, including assessment for personal or family history of medullary thyroid carcinoma or MEN 2, history of pancreatitis, severe gastrointestinal disease, and diabetic retinopathy

In an ideal world, youll never miss a dose
Funding This work was supported by the National Science and Technology Major Project (2022ZD0117700), the National Natural Science Foundation of China (32270759) and the Research Foundation for Postdoctoral (AUGA5710026124)
Medication or not, focus on making the healthiest choices possible, which means eating a diet with plenty of fruits and vegetables, protein, and whole grains
Patients with existing heart disease should discuss their options with their GP or specialist rather than drawing premature conclusions