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Abbreviations 2-HG: 2-Hydroxyglutarate -KG: -Ketoglutarate -SMH: -Smooth muscle actin ACLY: ATP citrate lyase ADT: Androgen deprivation therapy ALDH: Aldehyde dehydrogenase AMPK: 5-AMP-activated kinase AML: Acute myeloid leukemia AR: Androgen Receptor ARG: Arginase BPH: Bening prostatic hyperplasia CAF: Cancer-asssociated fibroblast CAIX: Carbonic anhydrase IX Cat2: Cationic amino acid transporter 2 CMP: CpG Methylator Phenotype CPT1: Carnitine palmitoyltransferase CSC: Cancer stem cell circRNA: Circular RNA CRPC: Castration-resistant prostate cancer ECM: Extracellular matrix EMT: Epithelial-to-mesenchymal transition ERG: ETS-related gene ESC: Embryonic stem cell ETC: Electron transport chain EV: Extracellular vesicle FAD: Flavin adenine dinucleotide FAO: Fatty acid oxidation FASN: Fatty acid synthase FH: Fumarate hydratase GABA: -Aminobutyric acid GAD: Glutamic acid decarboxylase GLS-1: Glutaminase 1 G-MDSC: Granulocytic MDSC GPNA: L--Glutamyl-p-nitroanilide HIF: Hypoxia inducible factor IDH: Isocitrate dehydrogenase IL-6: Interleukin-6 IL-8: Interleukin-8 iPSC: Induced pluripotent stem cell KDM: Histone lysine demethylase LDH: Lactate dehydrogenase LSH: Lymphoid-specific helicase mCRPC: Metastatic castration-resistant prostate cancer MCT: Monocarboxylate transporter MDH: Malate dehydrogenase MDSC: Myeloid-Derived Suppressor Cell MET: Mesenchymal-to-epithelial transition M-MDSC: Monocytic MDSC MPC: Mitochondrial pyruvate carrier MutIDH1/2: Mutated form of the enzyme isocitrate dehydrogenase NF-kB: Nuclear factor kB NK: Natural killer NPC: Nasopharyngeal carcinoma OXPHOS: Oxidative phosphorylation PARP: Poly-ADP ribose polymerase PC: Prostate cancer PCSC: Prostate cancer stem cell PGC1: Peroxisome proliferator-activated receptor co-activator 1 PHGDH: Phosphoglycerate dehydrogenase PI3K: Phosphoinositide 3-kinase PIN: Prostatic intraepithelial neoplasia PKM2: Pyruvate kinase M2 PPP: Pentose phosphate pathway PSA: Prostate specific antigen ROS: Reactive oxygen species SIRT: Sirtuin SOD: Superoxide dismutase SDH: Succinate dehydrogenase TAM: Tumor-associated macrophages TCA: Tricarboxylic acid cycle TERT: Telomerase reverse transcriptase TET: Ten eleven translocaion-enzyme TGF: Transforming growth factor TME: Tumor microenvironment VEGF: Vascular endothelial growth factor Wnt3: Wnt family member 3 References Ittmann M

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