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Several recent CVOTs have shown that GLP-1RAs can reduce the decline of estimated GFR (eGFR) and delay the onset of the occurrence of proteinuria in patients with T2DM [4, 22, 26, 46, 47]
262 The accumulation of amyloid fibrils in the cardiac extracellular matrix induces myocardial stiffness and conduction disturbances, leading to clinical manifestations such as HF and arrhythmias
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While many weight loss medications only target the GLP-1 receptor, tirzepatide is a dual agonist , meaning it targets both GLP-1 and GIP receptors
Withhold SYNJARDY or SYNJARDY XR, if possible, in temporary clinical situations that could predispose patients to ketoacidosis
