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Additionally, heme levels are closely related to iron overload

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2 Introduction In recent years, chronic kidney disease (CKD) incidence has doubled among older individuals, owing partly to increasing prevalence of conditions such as diabetes and hypertension that damage the delicate blood vessels of the kidneys (Liu 2010)

Laboratory studies demonstrate that senescent cancer cells maintain similar FOXO4-p53 interactions that protect them from apoptosis, making them susceptible to FOXO4-DRI-mediated elimination while providing researchers with tools for studying cancer cell senescence and survival mechanisms