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Using the safety and feasibility data from these first-inhuman trials demonstrating that intermittent D+Q was well tolerated in 50 subjects (NCT 02874989 and NCT 02848131), combined with the efficacy data in mouse models, we initiated a Phase I study of senolytic therapy in older adults with early-stage symptomatic AD, SToMP-AD (Senolytic Therapy to Modulate the Progression of Alzheimers Disease, NCT04063124) (107)

10.1126/scitranslmed.3009759 Sci

The water-based texture settles quickly without heaviness

The 0.9% benzyl alcohol concentration is not a conservative default

Proapoptotic activity of new glutathione S-transferase inhibitors