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The therapeutic usefulness of treatments can also be studied in terms of real-world evidence using aforementioned data sources such as electronic health records and observational studies, rather than exclusively under controlled conditions as in clinical trials

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142 In addition, GLP-1 RA upregulated neurotrophic tyrosine kinase receptor type 2 and mTOR genes in the hippocampus of high-fat-fed mice, which are involved in regulating synaptic plasticity and LTP

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