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Journal reference: Xie Y, Choi T, Al-Aly Z (2026)

Higher melanin levels result in darker skin tones, while lower melanin levels result in lighter skin tones

79 This route has not been seriously considered as a widely prescribed option for skin lightening treatments

Those participants were then re-randomized to take either orforglipron or a placebo pill for another 52 weeks, while continuing diet and physical activity counseling