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(For context, GIP is a hormone that works in tandem with GLP-1) (9)
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Extracellular NAD + can enter cells via pore-forming channel connexin 43 (Cx43), a bi-directional NAD + transporter allowing exogenous NAD + transportation into the cell, and transportation out for utilization of NAD + by CD38 64
Therefore, the answers to some questions remain unclear
Considering the previously reported effect of NaB on class I HDACs 38,39 , we further examined the role of HDACs in NaB-mediated GLP-1 expression
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