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Through the cleavage of the C-terminal dipeptide, ACE alters the molecular structure of bradykinin in KKS, causing a loss of function that results in vasoconstriction and elevated blood pressure
This stability profile is one reason the fragment was selected for further mechanistic study after its identification in the parent gastric protein
Glutathione is a powerful antioxidant that plays a crucial role in various bodily functions, including detoxification, immune system support, and the reduction of oxidative stress
a-c , Difference in abundance in the extracellular cysteinylglycine in medium (a) and relative abundance of intracellular cysteinylglycine (b) and intracellular cysteine (c) for HCC-1806 cells grown in the indicated conditions and time points (n = 3 technical replicates representative from 2 independent experiments, except for c at 24 h, in which n = 2 technical replicates from 2 independent experiments)
