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GHRP-6 and Hexarelin are earlier ghrelin-receptor agonists that act on the same receptor as Ipamorelin but trigger broader endocrine responses, including cortisol, prolactin, and ACTH elevations, which limits their usefulness as clean ghrelin-pathway reference tools

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Written consents for the use of blood for research purposes were obtained from the donors

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Another key difference between these two peptides is that ipamorelin does not adversely affect ACTH or cortisol, at least not based on the rat and swine studies [11]