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Compounds that appeared promising in preclinical and early clinical data have failed in later-phase trials repeatedly
Tissue collection Both BALF and whole blood were kept on ice and then centrifuged to separate the BAL cells and plasma, respectively
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Clinical trials with over 10,000 participants showed cancer incidence rates comparable to control groups, though rodent studies identified thyroid C-cell tumors leading to FDA warnings
Endothelial function improves with weight loss, allowing better vasodilation in response to physiologic demand The expected magnitude of BP improvement with weight loss is approximately 1 mmHg systolic per kilogram lost in the early phase, with smaller gains as weight loss progresses
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