Hydroxyureas efficacy varies among patients, and gene therapies, though effective, are limited by issues of accessibility and affordability
the chromatogram trace itself matters at least as much as the headline percentage
Nonetheless, the magnitude of weight reduction observed at higher doses is notable given that achieving substantial weight loss in individuals with type 2 diabetes has historically been more difficult than in those with obesity alone, partly due to the metabolic effects of the condition itself and certain antidiabetic medications
Before using compounded semaglutide and vitamin B12, tell your healthcare provider about All of your medical conditions
Highest dose, obesity trial obesity-plus-diabetes trial (treatment-policy estimand): Semaglutide: 14.9% (STEP 1) 9.6% (STEP 2), a 5.3 point gap Tirzepatide: 20.9% (SURMOUNT-1) 14.7% (SURMOUNT-2), a 6.2 point gap Retatrutide: 25.0% (TRIUMPH-1) 20.8% (TRIUMPH-2 only efficacy-estimand currently reported so true gap is larger) It's still unclear the reason why we observe less weight loss in those with T2D