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doi:10.1002/ptr.3502 Rodrguez-Ramiro I, Ramos S, Bravo L, Goya L, Martn M (2011) Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway

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7.3 Prospects Therefore, given the current situation and the challenges of insufficient clinical research, inconsistent efficacy, and unclear side effects, it is proposed that future efforts should focus on conducting large-scale, multicenter clinical studies to validate long-term efficacy, as well as research on drug side effects and dosage optimization

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