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New England Journal of Medicine , 368: 1575-1584 Zhu W, et al
This capacity to simultaneously combat tumor progression and protect normal tissues positions morin as a versatile therapeutic candidate
In preclinical animal models: wound closure accelerated (50% closure day 5 vs vehicle day 7, full-thickness excisional model), tendon tensile strength improved (+58% at day 14 vs vehicle, Achilles model), gastric lesion index reduced (6878% vs vehicle, ethanol ulcer model), inflammatory cytokines reduced (TNF- 4252%, IL-6 3844%, colitis model), angiogenesis stimulated (CD31+ MVD +44% vs vehicle), and neuroprotection demonstrated (NSS improved, lesion volume 2834%, TBI model)
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They actively contribute to endocrine homeostasis by repairing tissue damage caused by diseases such as pituitary adenomas, Addisons disease, and hypopituitarism
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