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The trial showed: Tirzepatide 5 mg: 7.6 kg weight loss Tirzepatide 10 mg: 9.3 kg weight loss Tirzepatide 15 mg: 11.2 kg weight loss Semaglutide 1 mg: 5.7 kg weight loss Some articles looked at those numbers and decided "tirzepatide 10 mg is roughly equivalent to semaglutide 1 mg" because 9.3 kg is about 1.6x more than 5.7 kg, and 10 mg is 10x more than 1 mg, so the "potency ratio" is around 6:1
Real-world evidence (Nature, 2023) A survey of 153 adults with obesity who were already taking semaglutide or tirzepatide found they reported a 73% reduction in weekly alcohol consumption, and their likelihood of binge-drinking dropped by about 80% compared to similar people not on medication
Individual results vary depending on starting weight, dose, lifestyle, and duration of treatment
tramadol Like oxycodone, tramadol is an opioid
Tirzepatide, a dual GLP-1 and GIP receptor agonist, has become one of the most effective medications for weight loss since FDA approval in 2023
