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With this biotransformation, liver detoxification, a long-standing barrier in nanomedicine translation, can be turned into a bridge toward maximizing targeting and minimizing nanotoxicity
For example, miR-30 families have been demonstrated to interact with DRP1 in several researches, 206,207,208 and it has been confirmed that the expression of miR-30b is upregulated in OA chondrocytes

Theyre promising for a few reasons

Chronic alcohol abuse reduces glutathione in the liver

This slower absorption may provide more sustained glutathione availability, though clinical significance of this difference remains unclear for most applications

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