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The part of our brain that controls our body weight (hypothalamus) notices any weight loss as starvation and unconsciously works via hormonal signaling to increase hunger and food cravings and decrease calorie burn to get your weight (specifically fat) back to where it was prior to weight loss

Huang Y, Liu L, Hao Z et al (2022) Potential roles of gut microbial tryptophan metabolites in the complex pathogenesis of acne vulgaris

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It is a good predictor of the effectiveness of any anti-obesity medication if patients lose 5% of their total body weight within the first three months

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