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Animal research using mice was conducted under a protocol approved by the UC Irvine Institutional Animal Care and Use Committee (IACUC) in compliance with the Animal Welfare Act and other federal statutes relating to animals and experiments using animals (Burke lab animal use protocol AUP-22-005 and AUP-25-004)

Here is what the clinical evidence actually says about which works better and for whom

The transformative breakthroughs in GLP-1 research recognized by the 2024 Lasker~DeBakey award

Over the longer term, because sermorelin raises growth hormone levels, your doctor will watch for signs of fluid retention, joint pain, or changes in blood sugar

The 5 mg vial (+ 3 mL bacteriostatic water) Worked out step by step at the documented 100 mcg dose (remember 100 mcg = 0.1 mg): Concentration: 5 mg 3 mL = 1.67 mg/mL Draw volume: 0.1 mg 1.67 mg/mL = 0.06 mL Units: 0.06 mL 100 = 6 units The 10 mg vial (+ 3 mL bacteriostatic water) Same diluent volume, double the powder, so the solution is twice as concentrated and the same dose occupies half the volume: Concentration: 10 mg 3 mL = 3.33 mg/mL Draw volume: 0.1 mg 3.33 mg/mL = 0.03 mL Units: 0.03 mL 100 = 3 units This is the single most important thing to internalize: the same 100 mcg dose is 6 units from a 5 mg vial but only 3 units from a 10 mg vial