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For example, 2-propyl-2-pentenoic acid (2-en-VPA), a byproduct of -oxidation, and 2-propyl-4-pentenoic acid (4-en-VPA), a byproduct of -oxidation, have been incriminated in the development of cerebral oedema and in the hepatotoxicity of VPA, respectively [1724]

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642 Together, ACMSD and NNMT provide novel targets for modulating NAD + homeostasis, which will be of great importance to determine whether ACMSD and NNMT inhibitors can increase NAD + levels and achieve therapeutic effects

Plaintiffs generally contend that slowing gastric emptying can, in some cases, progress from temporary digestive disruption to more serious problems involving the stomach muscles, including allegations described as stomach paralysis and complications like bowel obstruction

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