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For the majority of patients, the heart rate increase associated with GLP-1 receptor agonist therapy is not clinically significant and does not require treatment modification

This review examines the impact of obesity on the underlying mechanisms of HFpEF, summarizes the trial data on cardiovascular outcomes of GLP-1 RAs in patients with type 2 diabetes mellitus, and highlights the potential cardioprotective mechanisms of GLP-1 RAs to give a pathophysiological and clinical rationale for using GLP-1 RAs in obese HFpEF patients

Jetra, koja sintetizira najvie glutationa, u takvim uvjetima postane preoptereena i oteena i vie nije dovoljno efikasna za obavljanje detoksikacije